Possible Interaction: Cocaine and Fluoxetine

“ Fluoxetine antagonized the cue‐induced increase in cortisol but increased subjects' ratings of the likelihood of cocaine use in response to cocaine cues.”

“ Fluoxetine also attenuated the mydriatic effect of cocaine.”

“Median BE and cocaine concentrations in urine decreased significantly from intake to week 9 of fluoxetine treatment.”

“These findings suggest that perinatal exposure to fluoxetine perturbs adult serotonergic neurotransmission and produces a positive hedonic shift for conditioned reinforcing effects of cocaine.”

“Based on findings from studies on animals indicating that fluoxetine (an antidepressant) and cocaine (a psychostimulant) can increase MeCP2 expression in the brain, it is suggested that early intervention with antidepressants or psychostimulants could increase the normal MeCP2 expression in females with RTT, who are normally heterozygous.”

“In addition, fluoxetine might have enhanced the toxic effects of cocaine because of its weak pro-arrhythmogenic properties.”

“ResultsPretreatment with either the 5-HT transport inhibitor fluoxetine (5.6 mg/kg) or the 5-HT2C receptor agonist Ro 60–0175 (1 mg/kg) attenuated reinstatement of drug seeking by cocaine priming.”

“Our data shows that mice pretreated with FLX during adolescence, but not during adulthood, display an enhanced dose-dependent preference to the environment paired with cocaine (5 or 10 mg/kg) when compared to age-matched saline pretreated controls.”

“Taken together, our findings suggest that adolescent exposure to FLX increases sensitivity to the rewarding properties of cocaine , later in life.”

“Conclusions: These results suggest that chronic fluoxetine treatment decreases motivation for cocaine when animals are in a cocaine-free state.”

“The effects of a subeffective dose of cocaine were enhanced by a combination of subeffective doses of the serotonin reuptake inhibitor fluoxetine , the dopamine reuptake inhibitor GBR12909, and the noradrenaline reuptake inhibitor atomoxetine.”