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Last Updated: 5 months ago

Possible Interaction: Cocaine and Flunarizine

supplement:

Cocaine

Research Papers that Mention the Interaction

Pretreatment with flunarizine (3.0 mg/kg) produced rightward shifts of the cocaine and d-amphetamine dose-response curves.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
It is suggested that flunarizine , by blocking calcium influx into DA neurons, prevents DA release from dendrites, thereby counteracting the main mechanism by which cocaine inhibits dopaminergic neuronal activity.
Pharmacological research  •  1991  |  View Paper
While two dihydropyridine calcium antagonists, nimodipine (20 mg/kg) and isradipine (2.5 mg/kg), prevented cocaine-induced DA release and motor stimulation, the diphenylalkylamine-type calcium antagonist flunarizine (20 mg/kg) strongly potentiated both effects of cocaine.
European journal of pharmacology  •  1990  |  View Paper
Pretreatment with flunarizine (20 mg/kg), a diphenylalkylamine calcium channel antagonist, markedly potentiated cocaine (10 mg/kg)-induced dopamine (DA) output from the ventral striatum, as measured by microdialysis in freely moving rats.
European journal of pharmacology  •  1990  |  View Paper