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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Post hoc analyses showed that cocaine involvement only increased in the presence of fentanyl (linear ß = 1.41, p < 0.001; quadratic ß = 0.70, p < 0.001) and decreased when fentanyl was not present (linear ß=-0.81, p < 0.001; quadratic ß=-0.31, p < 0.001).”
Trends in substances involved in polysubstance overdose fatalities in Maryland, USA 2003-2019.“Background Numerous reports have led to concerns that fentanyl is added to many street drugs as an adulterant, including to stimulants like cocaine and methamphetamine, and could increase risks for negative health outcomes.”
“Consequently, harm reduction strategies should be broadened to include all patients at risk of fentanyl overdose, including patients who use substances (eg, cocaine ) that are potentially adulterated with fentanyl.”
“These observations suggest that fentanyl and cocaine together potentiate the underlying mechanism of injury, including the potential for both excitotoxic and hypoxicischemic processes; such an interaction may also explain some of the lesions identified outside the hippocampus (for example, those in the globus pallidus) in this patient and others.”
“Clients ever testing positive for fentanyl were significantly (p<0.05) more likely to use cocaine , have multiple treatment admissions to the clinic, and leave treatment sooner.”
“Morphine and fentanyl produced smaller decreases in cocaine self-administration, and undesirable effects precluded evaluation of higher fentanyl and morphine doses.”
Effects of mu-opioid agonists on cocaine- and food-maintained responding and cocaine discrimination in rhesus monkeys: role of mu-agonist efficacy.“Administration of either SNC 80 (0.1-1.0 mg/kg) or fentanyl (0.001-0.01 mg/kg) prior to cumulative doses of cocaine produced dose-dependent leftward shifts in the cocaine dose-response function.”
“Although pretreatment with fentanyl failed to alter the discriminative stimulus effects of low doses of cocaine , cocaine reversed the rate-suppressant effects of fentanyl.”
“Fentanyl availability and COVID-19 bring new HIV prevention challenges, particularly among those who inject fentanyl with cocaine , highlighting the importance to expand and sustain harm reduction, prevention, and treatment services for PWID to reduce HIV and overdose burden.”
HIV Risk Among Urban and Suburban People Who Inject Drugs: Elevated Risk Among Fentanyl and Cocaine Injectors in Maryland“Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl.”
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