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Last Updated: 4 months ago

Possible Interaction: Cocaine and Fentanyl

supplement:

Cocaine

Research Papers that Mention the Interaction

These observations suggest that fentanyl and cocaine together potentiate the underlying mechanism of injury, including the potential for both excitotoxic and hypoxicischemic processes; such an interaction may also explain some of the lesions identified outside the hippocampus (for example, those in the globus pallidus) in this patient and others.
Annals of Internal Medicine  •  2018  |  View Paper
Clients ever testing positive for fentanyl were significantly (p<0.05) more likely to use cocaine , have multiple treatment admissions to the clinic, and leave treatment sooner.
Journal of substance abuse treatment  •  2017  |  View Paper
Morphine and fentanyl produced smaller decreases in cocaine self-administration, and undesirable effects precluded evaluation of higher fentanyl and morphine doses.
The Journal of pharmacology and experimental therapeutics  •  2002  |  View Paper
Administration of either SNC 80 (0.1-1.0 mg/kg) or fentanyl (0.001-0.01 mg/kg) prior to cumulative doses of cocaine produced dose-dependent leftward shifts in the cocaine dose-response function.
Psychopharmacology  •  1998  |  View Paper
Although pretreatment with fentanyl failed to alter the discriminative stimulus effects of low doses of cocaine , cocaine reversed the rate-suppressant effects of fentanyl.
Pharmacology Biochemistry and Behavior  •  1995  |  View Paper
Background Numerous reports have led to concerns that fentanyl is added to many street drugs as an adulterant, including to stimulants like cocaine and methamphetamine, and could increase risks for negative health outcomes.
Harm Reduction Journal  •  2020  |  View Paper
Consequently, harm reduction strategies should be broadened to include all patients at risk of fentanyl overdose, including patients who use substances (eg, cocaine ) that are potentially adulterated with fentanyl.
The American journal on addictions  •  2020  |  View Paper
Breaking point values increased dose-dependently during both cocaine (0.125-1.00 mg/kg per injection) and fentanyl (0.25-2.00 μg/kg per injection) self-administration.
decreased breaking point values for both cocaine and fentanyl , reflecting a decrease in the reinforcing efficacy of the drugs.
Environmental toxicology and pharmacology  •  1997  |  View Paper