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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Fenfluramine
Research Papers that Mention the Interaction
“ Chronic cocaine exposure reduces some of the hormone responses to the serotonin (5-HT) releasers p-chloroamphetamine and d-fenfluramine , suggesting deficits in the functional status of serotonergic nerve terminals.”
Monoaminergic Regulation of Neuroendocrine Function and Its Modification by Cocaine“mCPP or fenfluramine significantly increased the expression of hypothalamic pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript genes while having no significant effects on the expression of hypothalamic neuropeptide Y, agouti- related protein, and ghrelin genes.”
A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice.“Thus, administration of phentermine + fenfluramine , having both dopamine-releasing and serotonin-releasing properties, respectively, may mimic the neurochemical activity by which cocaine acts in the central nervous system and may possibly allow for cocaine-like effects as these two drugs see increased use in obesity control.”
“The ACTH responses to d-fenfluramine and 8-OH-DPAT were inhibited in cocaine pretreated rats.”
“In addition, the 5-HT uptake blockers fluoxetine and cocaine inhibited the release induced by MDMA, methamphetamine, PCA and fenfluramine to the same percentage.”
“Blockade of morphine tolerance by cocaine was reinforced and facilitated by pretreatment with fenfluramine or p‐chlorophenylalanine ethyl ester and to a lesser extent by clonidine and haloperidol.”
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