Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Cocaine and Fasudil

supplement:

Cocaine

drug:

Fasudil

Research Papers that Mention the Interaction

FOXM1D-induced ROCKs activation could be abrogated by the ROCKs inhibitors Y-27632 and fasudil.
Oncogene  •  2017  |  View Paper
The inhibition of ROCKs by fasudil may offer a possible therapeutic tool for the pulmonary hypertension of the neonates.
American journal of physiology. Regulatory, integrative and comparative physiology  •  2016  |  View Paper
Fasudil also blocks habitual responding for cocaine , an effect that persists over time, across multiple contexts, and depends on actin polymerization.
Here the authors report that fasudil , a Rho kinase inhibitor, reduces dendritic spine densities on prelimbic neurons in an activity-dependent manner, stimulating goal-directed actions, and reducing habitual responding for cocaine.
Nature Communications  •  2017  |  View Paper