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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“However, the rewarding effects of cocaine were attenuated in mice pretreated with Ex-4 (Ex-4/Cocaine group, regardless of pretreatment dose), suggesting that Ex-4 reduces the hedonic effects of cocaine.”
“It is thus likely that Ex-4 blunts cocaine CPP by targeting GLP-1Rs within the NAc or ventral midbrain.”
“Moreover, even the lowest dose of Ex-4 used (10 µg/kg) produced a blunted cocaine CPP response, suggesting a GLP-1R-dependent mechanism involved in drug reward in addition to those already known involving neurotransmitters (e.g., dopamine, serotonin, norepinephrine, glutamate, and the opioids).”
“We show that administration of exendin-4 attenuates the rewarding effects of cocaine in mice, thus highlighting the therapeutic potential of GLP-1 receptor (GLP-1R) agonists for the treatment of psychostimulant addiction.”
GLP-1 analog attenuates cocaine reward“To this end, studies have reported that 'satiety' agents such as the glucagon-like peptide-1 receptor (GLP-1R) agonist, exendin-4 (Ex-4), decreases responding for addictive drugs such as cocaine , nicotine, alcohol, and oxycodone, but no work has been done with heroin.”
Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin-seeking behavior in rats.
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