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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cocaine and Ethylketocyclazocine

Research Papers that Mention the Interaction

When given in combination with cocaine, EKC produced effects that were sub-additive, suggesting that the kappa agonists may be used safely as cocaine abuse treatments.
European journal of pharmacology  •  2007  |  View Paper
Doses of EKC and U50,488 that decreased cocaine self-administration usually decreased food-maintained responding as well.
These results indicate that chronic administration of EKC and U50,588 produce a dose-dependent, kappa receptor-mediated and often sustained decrease in cocaine self-administration.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper
In myenteric plexus-longitudinal muscle preparations of isolated guinea pig ileum, 1 microM cocaine enhanced the agonistic effects of both pentazocine and ethylketocyclazocine.
Japanese journal of pharmacology  •  1988  |  View Paper