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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Epoprostenol
Research Papers that Mention the Interaction
“Conclusion: It is speculated that, when present in high concentrations, cocaine may affect vascular tone by inhibition of endothelial cell prostacyclin and PGE2 release.”
“Results: Cocaine produced a dose-dependent reduction in prostacyclin and PGE2 production from endothelial cells (p < 0.05).”
Cocaine affects prostaglandin production in human umbilical cord cell cultures“ Cocaine , normetanephrine and U-0521, augmented the positive inotropic influence of PGI2 on atria paced at a slow rate (0.8 Hz) but not at a faster one (3.3 Hz).”
Inotropic effect of prostacyclin (PGI2) on isolated rat atria at different contraction frequencies“ Cocaine significantly increased PGI2 plasma levels in arachidonate-treated rats in hypoxic respiratory conditions; in normoxic conditions cocaine left PGI2 levels unchanged.”
“Specific studies showed cocaine to have an inhibitory activity on prostacyclin release when the aortic tissue was mechanically and thermically stimulated.”
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