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Last Updated: 2 years ago

Possible Interaction: Cocaine and Epinephrine





Research Papers that Mention the Interaction

The temporal concordance between cocaine-induced stimulation of ACTH, epinephrine and subjective euphoria suggests that these hormonal changes are significant concomitants of the abuse-related effects of cocaine.
Psychoneuroendocrinology  •  2002  |  View Paper
Plasma epinephrine and norepinephrine concentrations were significantly increased in response to cocaine injection compared to placebo.
Pharmacology Biochemistry and Behavior  •  2001  |  View Paper
Results showed that the addition of adrenaline significantly reduced the systemic absorption of cocaine during surgery but caused no significant increase in toxic cardiovascular effects compared with the use of cocaine alone.
Clinical otolaryngology and allied sciences  •  1988  |  View Paper
In addition, recent use of cocaine increases the risk of a medical emergency during dental treatment, especially when epinephrine-containing local anaesthetics or retraction cords are used.
BDJ  •  2008  |  View Paper
Cocaine was shown to increase the effect of an epinephrine dose on the heart.
The Journal of pharmacology and experimental therapeutics  •  1952  |  View Paper
In 1903, Braun reported that adrenaline prolonged the local anesthetic effects of cocaine.
The Journal of craniofacial surgery  •  2020  |  View Paper
One of coca leaf compounds is cocaine which blocks the adrenaline and noradrenaline degradation by mean of monoamine oxidase inactivation.
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru  •  2015  |  View Paper
Patients at higher risk for serious adverse effects from epinephrine are those with comorbidities such as underlying heart disease and those taking monoamine oxidase inhibitors, tricyclic antidepressants, antiarrhythmics, and cocaine [8].
The American journal of emergency medicine  •  2013  |  View Paper
Cocaine is an indirect sympathomimetic agent that acts in the nervous system to block the presynaptic reuptake of serotonin and catecholamines (dopamine, norepinephrine and epinephrine ) and to increase their bioavailability at the post-synaptic receptors.
Clinical nephrology  •  2011  |  View Paper
Drugs such as cocaine and amphetamines potentiate the effect of epinephrine and norepinephrine on the brain and act as stimulants.
Sleep medicine  •  2006  |  View Paper
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