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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Cocaine and Ephedrine

supplement:

Cocaine

Research Papers that Mention the Interaction

It is suggested that cocaine desensitizes ephedrine blood pressure responses by depletion of norepinephrine depots.
Science  •  1961  |  View Paper
It has been demonstrated that cocaine will lessen some of the effects of ephedrine , chiefly cardiac output and blood pressure changes.
It is believed that the nature of the antagonism between ephedrine and cocaine is non-competitive, e. g., the two drugs combine with different parts of the receptor mechanism.
Journal of the American Pharmaceutical Association. American Pharmaceutical Association  •  1959  |  View Paper
Administration of cocaine suppressed the pressor effect of ephedrine and related compounds ; but administration of reserpine considerably removed the suppressive action of cocaine, though some difference was found according to the stage.
The Kurume medical journal  •  1971  |  View Paper
Cocaine , pyrilamine, and chlorpheniramine inhibited the atrial stimulation by tyramine and ephedrine.
Journal of pharmaceutical sciences  •  1969  |  View Paper