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Last Updated: 3 years ago

Possible Interaction: Cocaine and Enkephalin, Ala(2)-Mephe(4)-Gly(5)-

supplement:

Cocaine

drug:

Enkephalin, Ala(2)-Mephe(4)-Gly(5)-

Research Papers that Mention the Interaction

“Results: The mu-opioid selective agonist DAMGO , tested at doses of 0, 0.05 and 0.5 µg, produced a dose-related reduction in the number of cocaine infusions obtained during the 1-h self-administration sessions.”
Manipulations of mu-opioid and nicotinic cholinergic receptors in the pontine tegmental region alter cocaine self-administration in rats
Psychopharmacology  •  1999  |  View Paper
“At a dose of cocaine on the ascending limb of the self-administration dose-response curve, DAMGO microinfusions produced an increase in responding for the drug.”
“These experiments suggest that the mu agonist DAMGO is able to shift the dose-response curve for cocaine self-administration to the left.”
The mu opioid agonist DAMGO alters the intravenous self-administration of cocaine in rats: mechanisms in the ventral tegmental area
Psychopharmacology  •  1999  |  View Paper
“In the nucleus accumbens chronic cocaine led to an increase in both the number of mu-opioid receptors and the maximal inhibition of adenylyl cyclase activity by DAMGO ([D-Ala2,N-methyl-Phe4,Glyol]enkephalin).”
Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens.
European journal of pharmacology  •  1996  |  View Paper