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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In contrast to Romach et al. (Arch Gen …: 1101–1106, 1999), who showed that pretreatment with ecopipam … cocaine subjective effects, the current study found no attenuation of the subjective effects of nicotine, and thus, … support for the hypothesis that D1 receptors mediate the cocaine-like subjective effects of nicotine.”
Cocaine-like subjective effects of nicotine are not blocked by the D1 selective antagonist ecopipam (SCH 39166)“Conclusions: Maintenance on the long-acting dopamine D1 antagonist, ecopipam , enhanced both cocaine self-administration as well as its subjective effects compared to maintenance on placebo.”
“In the presence of active cocaine, ecopipam increased cocaine self-administration (12 mg) and increased ratings of "good drug effect," "high," "stimulated," and dose quality (25 and 50 mg).”
“Modafinil attenuated cocaine’s reinforcing effects in the human laboratory and improved treatment outcome, while ecopipam and aripiprazole increased the reinforcing effects of cocaine and do not appear promising in the clinic.”
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