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Last Updated: 4 months ago

Possible Interaction: Cocaine and Ecgonine

supplement:

Cocaine

Research Papers that Mention the Interaction

All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe.
Journal of analytical toxicology  •  2007  |  View Paper
During chronic oral dosing, there appeared to be a trend for AUC ratios (AUCmetabolite/AUCcocaine) of benzoylecgonine and ecgonine methyl ester to decrease and norcocaine to increase, indicating the possibility of dose-, time-, or route-dependent changes in the absorption and/or metabolism of cocaine.
Journal of analytical toxicology  •  1998  |  View Paper
Chemical inhibition of P450 enzymes further revealed that different P450-mediated oxidative reactions in the ecgonine and benzoic acid moieties of cocaine contribute to the species-dependent biotransformation of cocaine.
Drug Metabolism and Disposition  •  2013  |  View Paper
Pretreatment with EC inhibited both cocaine and BE seizures and seizure-associated death.
Brain Research Bulletin  •  1996  |  View Paper