Possible Interaction: Cocaine and Dopamine

“ Cocaine use causes an initial increase in dopamine and serotonin neurotransmission that is largely responsible for the pleasurable and reinforcing effects of the drug.”

“RationaleBecause the dopamine system appears to be involved in both acute and chronic effects of cocaine , medication development efforts for cocaine addiction have focused largely on agents that interact with the dopamine system.”

“Also, it interferes in cocaine induce brain reward stimulation and dopamine release.”

“CE and cocaine are equi-effective at blocking the reuptake of dopamine at receptor sites, thus reinforcing the stimulant effects of the neurotransmitter.”

“ Chronic cocaine potentiates excitatory and alters inhibitory transmission to dopamine neurons, induces dopamine neuron hyperexcitability, and reduces dopamine release in projection areas.”

“ Cocaine exposure induces persistent changes in synaptic transmission and intrinsic properties of ventral tegmental area (VTA) dopamine neurons.”

“ Cocaine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters such as dopamine and serotonin.”

“In utero cocaine exposure produces disruptions in brain monoamines, particularly dopamine , during sensitive periods of brain development, and leads to permanent changes in specific brain circuits, molecules, and behavior.”

“These findings indicated that TFF3 could potentiate behavioural response to cocaine , which may be associated with regulating dopamine concentration.”

“These findings suggest that chronic cocaine exposure-induced neuroplasticity in LDT cholinergic neurons may activate LDT cholinergic neurons, which in turn may enhance the activity of dopamine neurons in the VTA, leading to the development of cocaine addiction.”

“Addiction to psychostimulants, including cocaine and amphetamine, is associated with dysregulation of dopamine and serotonin (5-HT) neurotransmitter systems.”