Possible Interaction: Cocaine and Dopamine Antagonists

“The D1-selective dopamine receptor antagonist , SCH 23390, and the D2/D3-selective dopamine receptor antagonist, eticlopride, were significantly more effective in reducing the self-administration of cocaine in Brown Norway rats than for the other two strains.”

“Both … dopamine D3 receptor antagonist GR103691 (1 mg/kg) and the dopamine D4 receptor antagonist L745870 (1 mg/kg) partially antagonized the discriminative stimulus effects of cocaine (10 mg/kg) and the cocaine (10 mg/kg)-like discriminative stimulus effects of R(+)-7-OH-DPAT (0.3 mg/kg).”

“Maternal administration of a D1 dopamine antagonist , SCH 23390, before either cocaine or asphyxia exposure dramatically reduced the numbers of Fos-immunoreactive cells in the striatum as well as in many other brain regions.”

“The D1 dopamine antagonists SCH 23390, SCH 39166, and A-69024 dose-dependently shifted the cocaine dose-effect curve for locomotor activity to the right and decreased the efficacy of cocaine.”

“The D1 dopamine receptor antagonist SCH23390 (0.02, 0.1, or 0.5 mg/kg) or the D2 antagonist nemonapride (0.04, 0.2, or 1.0 mg/kg) significantly decreased cocaine augmentation of ICSS.”

“The dopamine receptor antagonist flupenthixol (0.032-0.56 mg/kg) attenuated the discriminative stimulus effects of heroin and completely blocked the discriminative stimulus effects of cocaine.”

“The increase in nucleus accumbens glutamate levels following cocaine (30 mg/kg) was calcium‐dependent and was blocked by pretreatment with dopamine antagonists ; haloperidol (0.2 mg/kg, i.p.),”

“These findings suggest that cocaine-induced behavioral sensitization may develop as a result of repeated dopamine D1- or D2-type receptor stimulation, and that brief dopamine antagonist treatments enhance subsequent behavioral sensitivity to cocaine.”

“In … the dopamine D1 antagonist SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro- 1H-3-benzazepine], … antagonist eticlopride and the dopamine D1/D2 antagonist flupenthixol produced dose-dependent blockade of gnawing induced by either cocaine or methylphenidate.(ABSTRACT … AT 250 WORDS)”

“Haloperidol (0.1 …/kg), the D1 dopamine antagonist 7-chloro-2,3,4,5-tetrahydro-3-methyl-phenyl-1-H-benzazepine-7-ol maleate (SCH23390) (0.01-0.… the D2 dopamine antagonist S(-)-sulpiride (20.0 and 40.0 mg/kg) only partially blocked the stimulus effects of cocaine.”