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Last Updated: 2 years ago

Possible Interaction: Cocaine and Donepezil

supplement:

Cocaine

Research Papers that Mention the Interaction

However, those treated with donepezil did show significant reductions in craving and other indexes of severity of addiction to cocaine and other drugs.8 To date, only one published study has evaluated galantamine as a treatment for addiction.
The American journal on addictions  •  2011  |  View Paper
Because AChE inhibitors have been shown to decrease the reinforcing effects of cocaine in animals, our hypothesis was that pretreatment with donepezil would attenuate the perceived value and other positive subjective effects of cocaine.
Drug and alcohol dependence  •  2010  |  View Paper
Group means for cocaine self-administration were decreased at some time points occurring between 1 and 3 days after the treatment with 10 mg/kg/day of donepezil (late effects), with decreases of more than 80% observed in some individual rats that persisted for 1 week or longer.
Behavioural pharmacology  •  2011  |  View Paper
Recently, a study showed that donepezil inhibited addictive behaviors induced by cocaine , including cocaine‐conditioned place preference (CPP) and locomotor sensitization to cocaine.
failed to inhibit locomotor sensitivity to METH, whereas pretreatment with 1 mg/kg donepezil significantly inhibited locomotor sensitivity to cocaine (10 mg/kg, i.p.).
Annals of the New York Academy of Sciences  •  2006  |  View Paper