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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Diphenhydramine
Research Papers that Mention the Interaction
“We have reported a synergistic interaction between cocaine and diphenhydramine (DPH) in a self-administration assay with monkeys.”
“When cocaine was combined with DPH or pyrilamine in a 1:1, 1:2 or 2:1 ratio of the ED(50)s, the combinations were super-additive as reinforcers.”
Super-additive interaction of the reinforcing effects of cocaine and H1-antihistamines in rhesus monkeys“It is proposed that … prejunctional action of cocaine and … diphenhydramine to reduce the rate of neuronal uptake of noradrenaline may provide a sufficient explanation for the enhanced reactivity of the vas deferens to noradrenaline, as this would allow an increased rate of rise of amine concentration at the receptors.”
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