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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“ Diazepam (5 mg/kg) but not haloperidol (0.16 or 0.64 mg/kg) significantly antagonized the discriminative stimuli produced by pentylenetetrazol and cocaine.”
Discriminative stimulus properties of cocaine related to an anxiogenic action.“ Cocaine and opioid abusers were six times more likely to abuse diazepam than any other BZ.”
“When responding for cocaine or saccharin was analyzed separately, we found that diazepam decreased responding for cocaine without affecting responding for saccharin.”
Diazepam promotes choice of abstinence in cocaine self‐administering rats“Findings that diazepam enhances cocaine self-administration and decreases cocaine response latency support the notion that cocaine-induced anxiety limits voluntary cocaine intake.”
“Comparable to withdrawal from ethanol, morphine, and diazepam treatments, withdrawal from oral self-administration of low to moderate doses of cocaine increases the rate of ultrasonic vocalizations while increasing minimally the amplitude of startle responses to low-intensity tactile stimuli.”
“We conclude that: (1) medio-ventral NAc is involved both in the rewarding (via a … dopaminergic mechanism) and aversive effects of cocaine in mice; and (2) anxiolytic pretreatment diazepam ) indirectly enhanced the … properties of cocaine in BALB/cByJ, suggesting that emotionality can … as a protective mechanism against stimulant abuse.”
“ Diazepam pre-treatment successfully antagonized the seizures induced by cocaine and lidocaine and raised the seizure threshold dose for the combination treatment by approximately four fold.”
“ Diazepam and phenobarbital protected against convulsions induced by 60 mg/kg cocaine (90% convulsions alone).”
“The effect of diazepam , haloperidol, MK-801, and propranolol in antagonizing behavioral symptoms induced by lethal doses of cocaine , amphetamine, and methamphetamine were studied in a rat model.”
“These data demonstrate that 1) chronic administration of cocaine produced sensitization for the PTZ stimulus, 2) tolerance developed to the behaviorally disruptive effects of cocaine, and 3) cocaine withdrawal produced a PTZ-like stimulus which was blocked by diazepam.”
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