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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Dextromethorphan
Research Papers that Mention the Interaction
“Generally, the DM analogs blocked these effects of cocaine at doses that did not display ataxic and sedative side effects as measured in the inverted screen test.”
“ Dextromethorphan has been reported to decrease the self-administration of several drugs of abuse, including morphine, methamphetamine, cocaine , and nicotine.”
Effects of dextromethorphan on dopamine release in the nucleus accumbens: Interactions with morphine“Combined treatments (30 min prior to each cocaine administration) with DM dose-dependently decreased locomotor activity for high doses of cocaine (20 mg/kg, i.p./day x 7).”
“Our results suggest that DM exhibits biphasic effects on the locomotor stimulation induced by cocaine , and that locomotor activities are in parallel with FRA-IR of the striatal complex.”
“ DM decreased the rate … higher doses of cocaine (0.5, 0.25 and 0.125 mg/kg/infusion), and increased the rate of responding for lower doses of cocaine (… 0.03 mg/kg/infusion), suggesting that DM shifted the dose-response curve for cocaine self-administration to the left.”
“ DEX pretreatment decreased the stimulating effects induced both by cocaine and amphetamine but no consistent dose-related effects were observed.”
“The results suggest that DEX may play an important role on the stimulating effects of cocaine and amphetamine and that it may be of some utility in the clinical management of psychostimulants abuse.”
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