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Last Updated: 2 years ago

Possible Interaction: Cocaine and Dexmedetomidine

supplement:

Cocaine

Research Papers that Mention the Interaction

For instance, dexmedetomidine is of great benefit in cocaine detoxification.
Journal of opioid management  •  2012  |  View Paper
Dexmedetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks.
Journal of the American College of Cardiology  •  2007  |  View Paper
Pretreatment with DM attenuated increases in heart rate, dP/dtmax, cardiac output, and pressure-work index produced by cocaine.
The results indicate that increases in heart rate, myocardial contractility, and myocardial oxygen consumption caused by cocaine were attenuated by DM pretreatment.
Anesthesia and analgesia  •  1995  |  View Paper
Premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity.
Iranian Red Crescent medical journal  •  2015  |  View Paper