Possible Interaction: Cocaine and Dexamethasone

“ Cocaine and other stimulants such as MDMA increase a blood glucose level and increase the risk of diabetic ketoacidosis in Type 1 DM.”

“Medications and other substances that can increase serum CK levels include the following: • amphotericin B • ampicillin • aspirin • anticoagulants • dexamethasone • furosemide • morphine • statins • alcohol • cocaine.”

“The … that DEX significantly inhibited … of cocaine- and amphetamine-regulated transcripts (CART), melanocortin receptor 4 (MC4R), and corticotropin-releasing hormone (CRH), and inhibited the protein level of the …-TOR compared with the control in HFD-fed chicks (P<0.05) but not in LFD-fed chicks (P>0.05).”

“Pretreatment with dexamethasone and then cocaine markedly enhanced the number of FOS-positive neurons in the LHb relative to cocaine treatment alone, suggesting that stress and addictive drugs exert a synergistic effect on the LHb.”

“Previous studies have demonstrated the capacity of a long-acting … of a naturally occurring bacterial double mutant cocaine esterase DM CocE) to antagonize the reinforcing, …, and lethal effects of cocaine in rodents and reverse the increases in mean arterial pressure (… heart rate (HR) produced by cocaine in rhesus monkeys.”

“In addition to dose-dependently recovering rats from an otherwise lethal dose of cocaine, post-treatment with DM CocE also reversed the cardiovascular effects of cocaine.”

“ DEX pretreatment decreased the stimulating effects induced by cocaine and amphetamine.”

“… DEX may play an important … central effects of morphine, cocaine and amphetamine through a differential modulation of brain excitability systems indicating that DEX may play an important role on the … morphine, cocaine and amphetamine and that it may be of some utility in the clinical management of psychastimuants abuse.”

“When compared to eyes treated with epinephrine alone, eyes pretreated with dexamethasone showed a significantly greater decrease in pressure at free base dexamethasone concentrations of 0.07%, 0.007% and 0.0007%, with the greatest difference at the 0.007% concentration (mean = 6.8 mm Hg).”

“ Cocaine , dopamine, and the D1 agonist inhibited neurite‐like process outgrowth in both dexamethasone and NGF‐induced GSras1 cells.”

“Additionally, the finding that dexamethasone blocks the acquisition of cocaine self-administration may be relevant to the development of novel approaches to the treatment of cocaine addiction.”

“ Dexamethasone dose-dependently attenuated the plasma corticosterone response to self-administered infusions or intraperitoneal injections of cocaine , indicating that the ability of dexamethasone to block cocaine-induced corticosterone secretion may have contributed to its effects on self-administration.”