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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Desipramine
Research Papers that Mention the Interaction
“Methadone impedes catabolism of desipramine so that relatively low doses of desipramine may produce antidepressant effects and possibly reduce the desire to use cocaine.”
Pharmacological and behavioral treatments of cocaine dependence: controlled studies.“Regardless of sex or opioid medication, desipramine increased opioid and cocaine abstinence more rapidly over time than placebo.”
“Together with the results of clinical trials of DMI for cocaine abuse, these laboratory results suggest that DMI may reduce cocaine craving both during and between cocaine binges.”
“Selective serotonin reuptake inhibitors may help to lower alcohol consumption in depressed patients, and desipramine may help to facilitate abstinence in persons addicted to cocaine.”
“Furthermore, the cardiovascular effects of desipramine appear to have the potential for toxicity when that drug is administered in combination with cocaine.”
“ Desipramine quickly reversed the withdrawal symptoms in both patients, although it did not prevent their future use of cocaine.”
“Preexposure to DMI attenuated aversions induced by cocaine.”
Possible role of norepinephrine in cocaine-induced conditioned taste aversions“In the ex vivo uptake assay, the addition of DMI to cocaine significantly increased the NE uptake inhibition compared to cocaine.”
“NE uptake inhibition by the mixture of cocaine and DMI at a ratio of 1:3 was evaluated in an ex vivo uptake assay.”
“However, chronic DMI treatment did reduce the amount of cocaine self-administered by the animals.”
“A low dose of either desipramine (3 mg/kg), fluoxetine (1.25 mg/kg), or GBR 12909 (2 mg/kg) coadministered with low doses of cocaine (0.625–2.5 mg/kg) enhanced the discriminative stimulus properties of this psychostimulant.”
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