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Last Updated: 3 years ago

Possible Interaction: Cocaine and Corticosterone

supplement:

Cocaine

Research Papers that Mention the Interaction

In rodents, corticosterone (cortisol in humans) facilitates cocaine self-administration purportedly via enhancement of dopaminergic activity in the brain.
Addictive behaviors  •  2005  |  View Paper
Despite the capacity for cocaine to increase corticosterone and adrenocorticotropic hormone levels in control mice, the hypothalamic‐pituitary‐adrenal axis was suppressed in HIV‐infected animals, and corticosterone levels were further decreased when animals were exposed to HIV and cocaine.
Journal of leukocyte biology  •  2005  |  View Paper
Increasing circulating levels of corticosterone also augments sensitivity to low doses of cocaine , possibly from a sensitization-associated phenomenon involving dopamine, suggesting that exposure to stress can increase individual vulnerability to cocaine.
The Journal of pharmacology and experimental therapeutics  •  2002  |  View Paper
Cocaine stimulates the secretion of corticosterone and ACTH, probably through a CRF-related mechanism, indicating that the drug activates the HPA axis.
Psychoneuroendocrinology  •  1997  |  View Paper
Taken together, these results suggest that corticosterone interferes with naturally occurring dopamine uptake locally, and this effect is a critical determinant of dopamine concentration specifically in situations in which the dopamine transporter is pharmacologically blocked by cocaine.
The European journal of neuroscience  •  2017  |  View Paper
The administration of cocaine resulted in an increase in corticosterone in the medial prefrontal cortex following vehicle pretreatment, which was not observed in the nucleus accumbens.
Psychoneuroendocrinology  •  2017  |  View Paper
Prenatal cocaine enhanced the CORT response to CRH/saline injections up to 60 min in males but not in females.
Brain Research  •  2011  |  View Paper
Corticosterone , the main glucorticoid hormone in rodents, facilitates behavioral responses to cocaine.
Addiction biology  •  2010  |  View Paper
We have studied the critical time-window for the influence of corticosterone on behavioural sensitisation to cocaine in relation to i) the stage of behavioural sensitisation, and ii) the time of drug exposure.
European journal of pharmacology  •  2009  |  View Paper
By contrast, cocaine attenuated corticosterone responses in C57BL/6 mice throughout the sensitisation paradigm.
Behavioural Brain Research  •  2007  |  View Paper
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