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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Cocaine and Carvedilol

supplement:

Cocaine

Research Papers that Mention the Interaction

The number of cocaine self-administrations was lower under 25 mg carvedilol treatment condition compared with 50 mg carvedilol or placebo treatment conditions.
These results suggest that acute treatment with carvedilol attenuates the physiological effects of smoked cocaine.
Drug and alcohol dependence  •  2000  |  View Paper
Further, CAR doses >25mg should not be used to avoid possible increases in cocaine and opioid use.
Journal of substance abuse treatment  •  2017  |  View Paper
Carvedilol affects the physiological and behavioral response to smoked cocaine in humans.
Trends in cardiovascular medicine  •  2016  |  View Paper
The solubility of S-CAR salts was promoted to approximately 3-32 times higher than that of the free base at pH 5.0-8.0.
Molecular pharmaceutics  •  2021  |  View Paper