Possible Interaction: Cocaine and Calcium Supplement

“ Cocaine has also been shown to block K+ channels, increase L-type Ca2+ channel current, and inhibit Na+ influx during depolarization, all possible causes for arrhythmia.”

“The vasoconstrictive effects of cocaine , concurrently with its effects on neuronal [ Ca 2 + ] i accumulation are likely to jeopardize neuronal tissue that in the prefrontal cortex (PFC) could contribute to impaired self-regulation and compulsive cocaine consumption.”

“These high levels of BE may contribute to the production … neurobehavioral alterations in cocaine-exposed offspring, given that this active cocaine metabolite has been shown to form molecular complexes with calcium ions (Misra and Mule 1975), thereby having the potential to influence a multiplicity of calcium-regulated developmental events.”

“Our results suggest that substances which can influence calcium distribution are involved in the rewarding actions of some drugs-morphine and cocaine.”

“Interestingly, 10(-7) M COC rapidly elevated intracellular free Ca++ concentrations of cultured cerebral vascular muscle cells about 50% over initial resting levels.”

“At a relatively high concentration (10(-3) M), cocaine significantly blocked an elevation of cytosolic calcium during potassium chloride-induced depolarization and significantly inhibited the release of calcium from sarcoplasmic reticulum by caffeine.”

“The result suggested that cocaine facilitated calcium contraction of individual cells in the tissue and induced larger contraction of the tissue.”

“It is suggested that cocaine makes a bound store of calcium more available to promote contraction of the spleen strip by noradrenaline.”

“The drugs procaine, cocaine and quinidine slightly stimulated the uptake of Ca++ by skeletal SRF; this mechanism is possibly related to their membrane-stabilizing activity.”

“The contractility of rat vas deferens was extremely dependent upon calcium concentration in the medium, and cocaine lowered the threshold concentration of calcium required for contraction.”