Possible Interaction: Cocaine and Bupropion

“This transport is blocked … psychostimulant drugs cocaine , l- and d-amphetamine, and phenyclidine), neurotoxins (6-hydroxydopamine and N-methyl-…-phenylpyridine (MPP))+), neurotransmitters (epinephrine, norepinephrine, gamma-aminobutyric acid, and serotonin), antidepressants (amitriptyline, bupropion , desipramine, mazindol, nomifensine, and nortriptyline), and various uptake inhibitors (mazindol, GBR 12783, GBR 12909, and amfonelic acid).”

“ Bupropion also consistently enhanced positive subject-rated effects of cocaine (e.g. good effects; willing to take again) while having no effects of its own.”

“We demonstrated that, similar to cocaine, the DAT blockers nomifensine and bupropion were less effective at inhibiting dopamine uptake following cocaine SA.”

“In a previous study, we reported that prenatal bupropion exposure seemed to enhance the hedonic value of cocaine in adult mice.”

“Two atypical inhibitors of the dopamine transporter, benztropine, used in the treatment of Parkinson's disease, and bupropion , used as an antidepressant, show very different psychostimulant effects when compared with another inhibitor, cocaine.”

“Results showed a decrease in catalase activity of the PFC and ST after SE and death induced by cocaine and bupropion overdoses.”

“The dopamine reuptake inhibitor bupropion increased the number of occurrences of lethality produced by (−) cocaine , while the dopaminergic D1 antagonist SCH 23390, the muscarinic M1 antagonist pirenzepine, and the sigma ligand (+) SKF 10047 all significantly, but only partially, antagonized (−) cocaine-induced lethality.”

“We believe clinicians should be aware of the potential for synergistic cardiovascular and CNS toxicity from concomitant cocaine and bupropion use.”

“We report acute toxicity from the concomitant use of cocaine and bupropion in a 25-year-old female.”