Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Journal of Pharmacology and Experimental Therapeutics • 2003 | View Paper
“3 Bretylium greatly enhanced the retention of [3 H]‐noradrenaline; when bretylium was added in the presence of cocaine , [3 H]‐noradrenaline retention was severely impaired.”
“7 The results are consistent with the view that both cocaine and sodium deprivation block the uptake of bretylium by the adrenergic nerve terminals, and that bretylium is probably taken up by a mechanism similar to or identical with the uptake system for noradrenaline and other amines.”
British journal of pharmacology • 1975 | View Paper
“The inhibition of the responses by bretylium was prevented by prior application of cocaine or desipramine and was reversed to the potentiation by cocaine when applied to preparations in which the inhibition had already been established.”
The Journal of pharmacology and experimental therapeutics • 1972 | View Paper
“The fact that cocaine , tripelennamine and chiorpheniramine antagonize the "anti-release" effect of bretylium indicates that bretylium may also use this "transfer site" to gain access to its site of action.”
British journal of pharmacology and chemotherapy • 1961 | View Paper
“This was shown by reversing cocaine desensitization through the administration of agents such as bretylium , which has a sparing effect on norepinephrine, and by the infusion of norepinephrine itself.”