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Last Updated: 3 months ago

Possible Interaction: Cocaine and Bretylium

supplement:

Cocaine

Research Papers that Mention the Interaction

Reboxetine (10-7 M) and cocaine (10-5 M) prevented the inhibitory action of bretylium (10-6 M).
Journal of Pharmacology and Experimental Therapeutics  •  2003  |  View Paper
3 Bretylium greatly enhanced the retention of [3 H]‐noradrenaline; when bretylium was added in the presence of cocaine , [3 H]‐noradrenaline retention was severely impaired.
7 The results are consistent with the view that both cocaine and sodium deprivation block the uptake of bretylium by the adrenergic nerve terminals, and that bretylium is probably taken up by a mechanism similar to or identical with the uptake system for noradrenaline and other amines.
British journal of pharmacology  •  1975  |  View Paper
The inhibition of the responses by bretylium was prevented by prior application of cocaine or desipramine and was reversed to the potentiation by cocaine when applied to preparations in which the inhibition had already been established.
The Journal of pharmacology and experimental therapeutics  •  1972  |  View Paper
The fact that cocaine , tripelennamine and chiorpheniramine antagonize the "anti-release" effect of bretylium indicates that bretylium may also use this "transfer site" to gain access to its site of action.
The Journal of pharmacology and experimental therapeutics  •  1966  |  View Paper
These sympathomimetic effects of bretylium were antagonized by cocaine.
The Journal of pharmacology and experimental therapeutics  •  1964  |  View Paper
Treatment with cocaine , imipramine or reserpine reduced the sensitivity to bretylium and guanethidine of the spinal cat.
British journal of pharmacology and chemotherapy  •  1963  |  View Paper
Cocaine was found to antagonize the action of bretylium on the response to eserine.
British journal of pharmacology and chemotherapy  •  1961  |  View Paper
This was shown by reversing cocaine desensitization through the administration of agents such as bretylium , which has a sparing effect on norepinephrine, and by the infusion of norepinephrine itself.
Science  •  1961  |  View Paper
Bretylium and atropine also inhibited the relaxation and cocaine increased it somewhat.
British journal of pharmacology and chemotherapy  •  1961  |  View Paper