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Possible Interaction: Cocaine and Benzoylecgonine

supplement:

Cocaine

Research Papers that Mention the Interaction

COC contamination with higher CE, BE or NCOC content produced significantly higher concentrations (P = 0.0001) of all analytes.
Journal of analytical toxicology  •  2012  |  View Paper
After a single injection of h2E2 (120 mg/kg) and cocaine hydrochloride (0.56 mg/kg), the concentration of cocaine and BE excreted into the urine of rats decreased by 92% and 91%, respectively, from vehicle controls.
Drug Metabolism and Disposition  •  2019  |  View Paper
In fact, benzoylecgonine can last in the body for a very long time (a few days) and, thus, is responsible for the long-term toxicity of cocaine and a commonly used marker for drug addiction diagnosis in pre-employment drug tests.
ACS chemical biology  •  2016  |  View Paper
These observations are consistent with an inhibition in vivo of esteratic metabolism of cocaine to benzoylecgonine , resulting in higher cocaine levels and metabolism through alternative pathways.
Drug metabolism and disposition: the biological fate of chemicals  •  1993  |  View Paper
Conclusions—Both cocaine and metabolites benzoylecgonine and cocaethylene induced endothelial VWF secretion, possibly explaining thrombotic risk after cocaine ingestion.
Arteriosclerosis, thrombosis, and vascular biology  •  2013  |  View Paper
If both substances were found (mean COC concentration 0.836 mg/L) the concentration of BZE was significantly higher (mean 0.669 mg/L) compared to cases with a single detection of BE (mean 0.209 mg/L) (p=0.001).
Forensic science international  •  2010  |  View Paper
Half lives of cocaine and BE were strongly correlated (Spearman rank rho=0.73; P<0.001).
Forensic science international  •  2009  |  View Paper
Moreover, the unpredictable extraction rate of both analytes, along with the hydrolysis of cocaine into BE significantly affects tissue concentrations, thus complicating the interpretation of quantitative results.
Forensic science international  •  2009  |  View Paper
During chronic oral dosing, there appeared to be a trend for AUC ratios (AUCmetabolite/AUCcocaine) of benzoylecgonine and ecgonine methyl ester to decrease and norcocaine to increase, indicating the possibility of dose-, time-, or route-dependent changes in the absorption and/or metabolism of cocaine.
Journal of analytical toxicology  •  1998  |  View Paper
The ratio of cocaine to benzoylecgonine ranged from 2-10:1.
Journal of forensic sciences  •  1998  |  View Paper
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