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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Benzoylecgonine
Research Papers that Mention the Interaction
“ COC contamination with higher CE, BE or NCOC content produced significantly higher concentrations (P = 0.0001) of all analytes.”
Cocaine analytes in human hair: evaluation of concentration ratios in different cocaine sources, drug-user populations and surface-contaminated specimens.“After a single injection of h2E2 (120 mg/kg) and cocaine hydrochloride (0.56 mg/kg), the concentration of cocaine and BE excreted into the urine of rats decreased by 92% and 91%, respectively, from vehicle controls.”
“In fact, benzoylecgonine can last in the body for a very long time (a few days) and, thus, is responsible for the long-term toxicity of cocaine and a commonly used marker for drug addiction diagnosis in pre-employment drug tests.”
“These observations are consistent with an inhibition in vivo of esteratic metabolism of cocaine to benzoylecgonine , resulting in higher cocaine levels and metabolism through alternative pathways.”
“Concentrations (ng/mL) of cocaine (249.30) and BZE (137.90) were higher when both substances were detected together than when detected alone.”
“If hands were washed prior to giving a fingerprint, BZE was detected only after the administration of cocaine.”
“Conclusions—Both cocaine and metabolites benzoylecgonine and cocaethylene induced endothelial VWF secretion, possibly explaining thrombotic risk after cocaine ingestion.”
“If both substances were found (mean COC concentration 0.836 mg/L) the concentration of BZE was significantly higher (mean 0.669 mg/L) compared to cases with a single detection of BE (mean 0.209 mg/L) (p=0.001).”
“Half lives of cocaine and BE were strongly correlated (Spearman rank rho=0.73; P<0.001).”
“Moreover, the unpredictable extraction rate of both analytes, along with the hydrolysis of cocaine into BE significantly affects tissue concentrations, thus complicating the interpretation of quantitative results.”
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