Possible Interaction: Cocaine and Aripiprazole

“ Aripiprazole significantly increased cocaine (12, 25 mg) self-administration.”

“Following a single administration of cocaine (25 mg), aripiprazole decreased ratings of how much participants would pay for that dose.”

“Following repeated cocaine (50 mg) self-administration, aripiprazole decreased ratings of cocaine quality, craving, and good drug effect as compared to placebo.”

“This experience suggests possible aripiprazole effects in lowering both desire for and the use of cocaine in comorbid SCHZ subjects.”

“Modafinil attenuated cocaine’s reinforcing effects in the human laboratory and improved treatment outcome, while ecopipam and aripiprazole increased the reinforcing effects of cocaine and do not appear promising in the clinic.”

“ Aripiprazole , a recently introduced atypical antipsychotic with D-sub-2 partial agonist actions, has been studied in mice, rats, and man, but its ability to attenuate abuse- and addiction-related effects of cocaine or methamphetamine remains controversial.”

“Because cocaine affects dopamine and serotonin, this study assessed whether aripiprazole could diminish the reinforcing efficacy of cocaine.”

“However, for most measures, fewer doses of cocaine were significantly greater than placebo when combined with aripiprazole , suggesting a reduction in the discriminative stimulus, self-reported and cardiovascular effects of cocaine.”

“ Aripiprazole was generally devoid of effects, but did alter temperature-increasing and subject-rated effects of cocaine as a function of cocaine dose.”

“Animals treated with aripiprazole in the open‐field, but not in the home‐cage, showed a blunted response to cocaine when receiving a cocaine challenge for the first time.”

“ Aripiprazole decreased acute cocaine hyperlocomotion in a context‐dependent manner.”

“ Aripiprazole decreased the expression of conditioned hyperlocomotion to cocaine.”

“Thus, aripiprazole at lower doses was the most selective antipsychotic drug concerning the inhibition of the development of behavioural sensitization to cocaine.”

“As a pharmacological parallel, coadministration of the high-affinity D2 agonist, aripiprazole , reduces not only functional downregulation of D2s in response to cocaine but also potentiation of NMDAR and AMPAR responses in wild-type mice.”