supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Cocaine
drug:
Antipsychotic Agents
Research Papers that Mention the Interaction
“Animal studies indicate that typical antipsychotics neuroleptics ) increase cocaine and amphetamine self-administration.”
Cocaine and Amphetamine Use in Patients With Psychiatric Illness: A Randomized Trial of Typical Antipsychotic Continuation or Discontinuation“In 96 subjects with cocaine toxicity treated with an antipsychotic , there were three deaths, two cardiac arrests, two seizures, and one episode of hyperthermia.”
“Pharmacodynamic approaches include antipsychotics that are thought to interfere with cocaine ’s actions at several neurotransmitter receptors.”
“Among 429 addiction treatment inpatients screened, 73 (17.0%) reported misuse of antipsychotics with alcohol, opioids, cocaine , methamphetamine and/or cannabis; 39 (9.1%) within the past year.”
“OBJECTIVE Since cocaine and psychostimulant dependence are related to increased dopamine release, antipsychotics have been tried to reduce their reinforcing properties.”
“When reported in the setting of a dystonic reaction, cocaine has been described as a predisposing factor for the patient already using neuroleptic agents.”
“However, our findings suggest that administration of an atypical antipsychotic for 10 days may increase the toxic effects of cocaine.”
Administration of ziprasidone for 10 days increases cocaine toxicity in mice“In addition, and possibly most importantly, there are several reasons a priori why we think antipsychotics may be inappropriate to administer to patients with cocaine toxicity.”
“The ability of this atypical antipsychotic candidate to alter the discriminative stimulus effects induced by cocaine or methamphetamine in rats or the stimulation of locomotor activity in mice was evaluated.”
“Intravenous self-administration of cocaine is extremely sensitive to the effects of antipsychotic drugs , making this behavior a useful screen for neuroleptic potency.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback