Possible Interaction: Cocaine and Adrenocorticotropic Hormone

“ Cocaine stimulates the release of adrenocorticotropin hormone (ACTH) and cortisol in both clinical and preclinical studies, but the temporal sequence of cocaine-induced changes in other hormones and affective states is unclear.”

“The temporal concordance between cocaine-induced stimulation of ACTH , epinephrine and subjective euphoria suggests that these hormonal changes are significant concomitants of the abuse-related effects of cocaine.”

“ Cocaine induced a significantly greater increase in ACTH in the occasional cocaine users than in the cocaine dependent men (p < .01).”

“Cigarette smoking and IV cocaine each stimulated a rapid increase in LH and ACTH , followed by gradual increases in cortisol and DHEA.”

“ Cocaine stimulates the secretion of corticosterone and ACTH , probably through a CRF-related mechanism, indicating that the drug activates the HPA axis.”

“Preclinical and clinical studies have shown that cocaine increases plasma adrenocorticotropin hormone (ACTH) and cortisol.”

“ Cocaine produced a mean increase from baseline of 261% for ACTH and 73% for cortisol plasma levels.”

“ Cocaine has been shown to alter circulating levels of the neurotransmitters, dopamine, norepinephrine, epinephrine, as well as the hypothalamic-pituitary-adrenal axis hormones corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH), and cortisol.”

“The 20 mg/kg dose of cocaine induced a significant decrease in ACTH levels 60 min after being administered.”

“ Cocaine stimulates the rapid release of ACTH , and by inference, CRF in several species, suggesting that the HPA "stress" axis may contribute to the abuse-related effects of cocaine.”

“PCP, TCP and cocaine increased plasma levels of adrenocorticotropin and corticosterone, but BTCP had no effect.”