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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cobalt
drug:
Phenylephrine
Research Papers that Mention the Interaction
“Superfusion with low calcium (0.1 mM), high magnesium (10 mM) and either cobalt (2‐4 mM), or cadmium (100 microM) usually reduced the response to phenylephrine and produced reversals near that predicted for potassium conductance.”
Differential responses of lateral and ventrolateral rat periaqueductal grey neurones to noradrenaline in vitro.“ Cobalt ions (2 mM) inhibited the glycogenolysis induced by phenylephrine and glucagon in perfused rat liver.”
“ Cobalt ions also inhibited 45Ca++ efflux from prelabelled livers induced by phenylephrine and glucagon.”
“These data suggest that cobalt ions, presumably through their high affinity for calcium binding sites on membranes inhibit the stimulation of glycogenolysis by phenylephrine and glucagon in distinct ways; one by inhibiting calcium mobilization and the other by inhibiting cyclic AMP production.”
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