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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cobalt
drug:
Norepinephrine
Research Papers that Mention the Interaction
“Threshold concentrations of cobalt produced marked potentiations of contractile responses to either norepinephrine (NE) or KCl.”
Cobalt contraction of vascular smooth muscle is calcium dependent.“ Noradrenaline uptake was maximally reduced … 8-10 after cortical cobalt application, a time corresponding to the onset of epileptic discharges; it remained diminished during the spiking activity period of the … 14-20) and was back to normal values at day 40, at which time the epileptic syndrome had disappeared.”
“Stimulation of the release of ACTH-, endorphin-, lipotropin-, and 16k fragment immunoreactive material by norepinephrine was fully blocked by cobalt ; by this criterion, stimulated release was calcium dependent.”
“3 Preliminary results with these computer‐generated drug response histograms revealed manganese, cobalt , and verapamil to be generally ineffective as antagonists of noradrenaline , despite their direct depressant effects.”
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