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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Cobalt
drug:
Hexobarbital
Research Papers that Mention the Interaction
“Two hours after subcutaneous injection of toxic doses, only cobalt nitrate significantly prolongs hexobarbital sleep.”
Influence of the acute intoxication with salts of some heavy metals on hexobarbital sleep and hexobarbital metabolism.“The prolonged hexobarbital sleep in rats subjected to subacute intoxication with cobalt , cadmium, nickel, copper and lead is probably due to a considerable extent to the inhibition of the hexobarbital metabolism by these metals.”
“Divalent cobalt in low concentration caused enhanced microsomal metabolism of hexobarbital , but was inhibitory with other substrates.”
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