Possible Interaction: Cobalt and Glutathione

“At the same time, Co and Co-NC decreased glutathione level (1.8 and 1.9 times, respectively) and activated vitellogenesis (5.1 and 9.9 times, respectively) in the fish liver.”

“Biliary GSH and GSSG increased 1 h after cobalt treatment and were twice control values 3 h after treatment.”

“The activation of antioxidant enzymes, such as …, as well as ascorbic acid and glutathione might be involved in capturing reactive oxygen species … treated with Co. Metabolomics analysis revealed that Co stress significantly increased the production of several amino acids (except …) and organic acids (with the exception of succinic acid).”

“ Co and Cu applied alone or in combination at rate of 50 μM resulted in the significant reduction of plant growth … MDA), and meanwhile the capacity of scavenging active oxygen species (AOS) was enhanced, reflected by increased phytochelatin (PC) and glutathione (GSH and GSSG) content, … genes (HvPCS1 and HvGR1).”

“Barley seedlings … 100µM Co showed the significant reduction in growth and photosynthetic rate, and the dramatic … the contents of reactive oxygen species (ROS), malondialdehyde (MDA), reduced glutathione ( GSH ) and oxidized glutathione (GSSG), and the activities of anti-oxidative enzymes, … (Co-sensitive) being much more affected than Yan66 (Co-tolerant).”

“Thus cobalt is relatively ineffective in the absence of glutathione , while the latter has no influence in the absence of cobalt.”