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Investigative ophthalmology & visual science • 1994 | View Paper
“Spiking activity is enhanced in high calcium , diminished in frequency and amplitude by lowered extracellular calcium and is blocked by cobalt and verapamil.”
Cell biology international reports • 1986 | View Paper
“The active depolarizing response is unaffected by either decreasing the external sodium concentration or by adding tetrodotoxin (3 × 10−5 M), whereas increasing the external calcium concentration increases both the spike amplitude and rate of rise, and the addition of cobalt (3 mM) blocks the response.”
“The stimulatory effect of increased calcium was blunted in the presence of 0.5 mM cobalt , which itself stimulated renin secretion at normal (0.5 mM) calcium concentrations.”
“However, treatment with cobalt , which blocks calcium and calcium-dependent currents, blocked the histamine response, suggesting that histamine decreases calcium activated potassium currents.”
“We found that calcium entry is both necessary and sufficient to induce axonal degeneration after axotomy, and may be inhibited by cobalt , manganese, dihydropyridines, and bepridil.”