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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ResultsSupplementation with both AA and A2P antagonized normoxic as well as cobalt chloride- and PHD inhibitor ethyl 3, 4-dihydroxybenzoate induced HIF-1α protein stabilization and transcriptional activity.”
Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells“ Cobalt at concentrations sufficient to stabilize HIF‐1α both oxidized intracellular ascorbate and induced an oxidant stress in the cells that was prevented by ascorbate.”
“Whereas the interaction of ascorbate and cobalt is complex, the presence of physiologic low millimolar concentrations of ascorbate in endothelial cells effectively decreases HIF‐1α expression and protects against cobalt‐induced oxidant stress.”
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