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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clozapine
supplement:
Tryptophan
Research Papers that Mention the Interaction
“ Clozapine also decreased plasma tryptophan , plasma homovanillac acid (HVA) and basal plasma cortisol levels.”
Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia“A marked decrease was observed in the concentration of liver tryptophan, whereas, the brain tryptophan concentration is significantly increased (p < 0.05) in response to clozapine treatment.”
Alterations in the level of neurotransmitters associated with the chronic treatment of antipsychotic drugs.“ Clozapine also elevates the plasma concentration of free tryptophan, and reduces the plasma concentration of total tryptophan.”
“ Clozapine , but not chlorpromazine, haloperidol, thioridazine, or loxapine, increases the concentrations of tryptophan , serotonin, and 5-hydroxyindoleacetic acid in the brain of the rat.”
“Therefore, clozapine may increase the brain serotonin concentration by enhancing the availability of tryptophan in the brain, thereby promoting serotonin synthesis.”
“ Clozapine also elevates the plasma concentration of free tryptophan, and reduces the plasma concentration of total tryptophan.”
“ Clozapine , but not chlorpromazine, haloperidol, thioridazine, or loxapine, increases the concentrations of tryptophan , serotonin, and 5-hydroxyindoleacetic acid in the brain of the rat.”
“Therefore, clozapine may increase the brain serotonin concentration by enhancing the availability of tryptophan in the brain, thereby promoting serotonin synthesis.”
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