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Last Updated: 3 years ago

Possible Interaction: Clozapine and Marijuana

supplement:

Marijuana

Research Papers that Mention the Interaction

After adjusting for diagnosis and illness chronicity, participants taking clozapine had significantly lower odds of current alcohol, cannabis and other drug use despite similar lifetime odds.
Epidemiology and Psychiatric Sciences  •  2016  |  View Paper
Cannabis use decreased in patients treated with clozapine , compared to patients treated with other antipsychotics (OR 2.8; 95% CI 0.97-7.9).
Compared to no medication, clozapine exposure was associated with significantly less cannabis use (OR 7.1; 95% CI 2.3-22.3).
Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent  •  2017  |  View Paper
Conclusions: Clozapine may reduce cannabis use among patients with schizophrenia and co-occurring cannabis use disorder.
Results: The two groups differed in average intensity of cannabis use by approximately 4.5 joints/week, with lesser use in the clozapine group (t = −1.77; df = 28.5; p = .086; effect size ∼ 0.6).
Journal of dual diagnosis  •  2011  |  View Paper