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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clozapine
supplement:
Green Tea Extract
Research Papers that Mention the Interaction
“Conversely, green tea extract and/or (-)-epigallocatechin-3-gallate reduce the bioavailability of quetiapine, sunitinib, clozapine , and nadolol.”
An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis).“Because of this reduction in AUC and Tmax of clozapine by green tea extract pretreatment, we suggest that both the rate and amount of absorption of clozapine may be reduced by green tea extract, although the hepatic elimination phase may not be significantly altered.”
“The mean total area under the plasma concentration‐time curve (AUC0‐∞) and maximal peak plasma concentration (Cmax) of clozapine in the green tea extract group were significantly lower than those of controls.”
Effects of green tea extract administration on the pharmacokinetics of clozapine in rats
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