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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clozapine
supplement:
Glutathione
Research Papers that Mention the Interaction
“Serum level of GSH and negative symptoms in patients receiving clozapine showed a negative correlation.”
Alterations in oxidative stress markers and its correlation with clinical findings in schizophrenic patients consuming perphenazine, clozapine and risperidone.“Similarly, when oxygen consumption was measured in peroxidase systems in the presence of glutathione or NADPH, the rate of oxygen uptake was markedly enhanced upon addition of clozapine.”
“ CLZ treatment increased the serum levels of cardiac injury (CK-MP, LDH and cTn-I) and cardiac levels of oxidative stress (TBARS and NO) markers, proinflammatory cytokines (IL-1β and TNF-α), and mRNA expression of VIM and CX43 with decreased the antioxidant defenses ( GSH and GSH-Px).”
The role of vimentin, Connexin-43 proteins, and oxidative stress in the protective effect of propranolol against clozapine-induced myocarditis and apoptosis in rats.“ CLZ caused a significant decrease in SOD (p < 0.001) and GSH (p < 0.01) with no effect on CAT.”
“The simultaneous appearance of both Cl and S is consistent with covalent binding of clozapine to glutathione.”
Studying the reaction between clozapine and glutathione with element-selective detection.
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