Possible Interaction: Clozapine and Glucose

“These findings provide evidence that glucose improves declarative memory in patients with schizophrenia who were treated with clozapine , and underscore the possibility of developing effective protocols to reduce cognitive dysfunctions in the disorder.”

“ Clozapine and olanzapine seem to have the greatest potential to induce glucose and lipid metabolism abnormalities, and risperidone has the least.”

“In conclusion, a single administration of clozapine increased the serum concentration of glucose in rats, and adrenaline and/or glucagon would be associated with clozapine-induced acute hyperglycemia.”

“The serum concentrations of glucose , adrenaline, and glucagon increased dose-dependently after the administration of clozapine at 2.5-10 mg/kg, and reached maxima at 5 mg/kg of clozapine.”

“The greatest effect on glucose dysregulation was noted primarily with clozapine and olanzapine; however, all four treatments caused significant increases in fasting glucose and/or insulin levels with the high dose, 60 min post-drug administration.”

“Both clozapine and olanzapine, as well as risperidone, decreased peripheral glucose utilization.”

“Moreover, 7 days of culture with clozapine inhibited insulin secretion stimulated by: (1) membrane depolarisation induced by high K+; (2) protein kinase C activation; and (3) mastoparan at 16.7 mmol/l glucose under stringent Ca2+-free conditions.”

“ Glucose significantly reduced the number of spontaneously active A9 and A10 dopaminergic cells per track in control rats, but significantly attenuated the chronic haloperidol- and clozapine-induced reductions in dopaminergic cells per track.”

“In addition the activity of clozapine is inhibited of the absorption spectra in the presence of glucose and enhanced in the presence of iron(III).”