Possible Interaction: Clozapine and Dextroamphetamine

“In WT mice, clozapine (1 mg kg–1) and NT69L (1 mg kg–1) significantly blocked d-amphetamine-induced disruption of PPI.”

“ConclusionsThe results show that clozapine diminished the rhythm and vigor of d-amphetamine-induced stereotyped head movements but, at the same time, lengthened the duration of the expression of the stereotypy.”

“The suggestion that clozapine inhibits the excitatory effect of D-amphetamine is further supported by the finding that clozapine, given after D-amphetamine, reliably reversed D-amphetamine-induced excitation in raclopride-treated rats.”

“ Clozapine blocked the generalization of the drug discrimination response to d-amphetamine , but had no effect on generalization to cocaine.”

“On the contrary, clozapine --antagonist of the D4 subtype of dopamine receptors--failed to reduce the stimulant action of d-amphetamine , but significantly decreased the effect of sydnocarb under the same experimental conditions.”

“Classical antipsychotics (haloperidol, fluphenazine and cis(Z)-flupentixol) and the selective dopamine D2 receptor … remoxipride inhibit hypermotility in the two conditions with similar potencies, whereas sertindole, clozapine , risperidone, ziprasidone and olanzapine preferentially inhibit the effect of the low dose of D-amphetamine (selectivity ratios between 6.5 and 18).”

“ Clozapine significantly attenuated the sniffing produced by 1.0 mg/kg d-amphetamine as well as the oral behavior (licking and/or biting) produced by 5.0 mg/kg d-amphetamine.”

“Both clozapine and prazosin inhibited the d-amphetamine-induced locomotor stimulation in mice.”

“Other postsynaptic alpha 1-antagonists, such as haloperidol, phenoxybenzamine and clozapine , were also effective in blocking this response to d-amphetamine.”

“Similarly, clozapine , but not haloperidol, reversed the depression of firing rate produced by 1.0 mg/kg d-amphetamine.”