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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clotrimazole
supplement:
Tretinoin
Research Papers that Mention the Interaction
“An evaluation of IC50’s versus in vivo Cmax values suggests that inhibitors such as clotrimazole or fluconazole may interact with CYP26 at clinically relevant concentrations and may alter levels of retinoic acid.”
Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases“Metabolism of [3H]-retinoic acid by TA3 Ha cells was inhibited by the cytochrome P-450 inhibitors ketoconazole, clotrimazole , and liarozole.”
A rapid assay for measuring the metabolism of [3H]-retinoic acid in cell cultures.“ Clot lysis was dose dependently increased by retinoic acid up to about 170% (relative to vehicle treated rats) at a dose of 3 mg/kg.”
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