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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Clotrimazole
supplement:
Progestins
Research Papers that Mention the Interaction
“ Clotrimazole inhibited steroid production in a dose-dependent manner with IC50 values for CYP17A1 and CYP19A1 in the range 0.017 - … the hydroxylase axis (IC50 MIC: 0.042-0.082 µM, KET: 0.041-1.2 µM), leading to accumulation of progestagens and corticosteroids and suppression … particular lyase activity.”
The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax.
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