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Last Updated: 3 years ago

Possible Interaction: Clopidogrel and St John's Wort

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drug:

Clopidogrel

supplement:

St John's Wort

Research Papers that Mention the Interaction

“We evaluated whether St. John's wort (SJW), a CYP2C19 and CYP3A4 inducer, enhances the pharmacodynamic response of clopidogrel.”

The Effect of St John's Wort on the Pharmacodynamic Response of Clopidogrel in Hyporesponsive Volunteers and Patients: Increased Platelet Inhibition by Enhancement of CYP3A4 Metabolic Activity

Journal of cardiovascular pharmacology • 2011 | View Paper

“Augmented antiplatelet effects are anticipated when clopidogrel is coprescribed with aspirin, curcumin, cyclosporin, St John’s wort , rifampicin, and angiotensin-converting enzyme inhibitors.”

Pharmacokinetic drug interactions with clopidogrel: updated review and risk management in combination therapy

Therapeutics and clinical risk management • 2015 | View Paper

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