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Last Updated: 2 years ago

Possible Interaction: Clonidine and Yohimbine

supplement:

Yohimbine

Research Papers that Mention the Interaction

Clonidine reduced and yohimbine increased colonic perception of pain but not gas sensation during distension.
The American journal of physiology  •  1997  |  View Paper
The combined treatment with clonidine + yohimbine reduced REM sleep, but not as extensively as clonidine alone; the Hjorth parameters were without significant alterations compared to placebo.
The physiological hypotonia was enhanced by clonidine and the combined treatment with clonidine + yohimbine.
Electroencephalography and clinical neurophysiology  •  1985  |  View Paper
Twitch and tonic contractions induced by clonidine were inhibited by yohimbine.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi  •  2006  |  View Paper
The effects of clonidine were blocked by yohimbine , a specific alpha2-adrenergic antagonist, but not by phentolamine, an alpha1-adrenergic antagonist.
The Journal of parasitology  •  2005  |  View Paper
In addition, clonidine (pD2 = 10.28) inhibited electrical field stimulation-evoked contractile responses in human saphenous vein which were blocked by yohimbine (30 nM, pA2 = 9.92) but did not alter the (R)-alpha-methylhistamine dose response curve.
European journal of pharmacology  •  1999  |  View Paper
Clonidine (3 × 10−9 to 3 × 10−7 M) blocked concentration‐dependently the contractile response to electrical field stimulation of human prostate and this inhibitory effect was reversed by yohimbine (10−7 M).
British journal of pharmacology  •  1995  |  View Paper
Cirazoline was the most potent to inhibit [3H]clonidine binding although yohimbine was also able to displace binding in the human NRL but with lower apparent affinity.
European journal of pharmacology  •  1989  |  View Paper
Functional studies on the conscious guinea-pig have shown that clonidine can potentiate the bronchoconstrictor effects of acetylcholine, histamine and serotonin (fig. 3) and that this potentiating effect is specifically inhibited by yohimbine and piperoxan (fig. 4).
Journal de pharmacologie  •  1985  |  View Paper
The alpha-2 adrenergic antagonist yohimbine reversed the effects of clonidine in blocking withdrawal.
The Journal of pharmacology and experimental therapeutics  •  1985  |  View Paper
Jumping potentiated by clonidine was antagonized by yohimbine whereas prazosin had no effect.
Naunyn-Schmiedeberg's archives of pharmacology  •  1985  |  View Paper
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