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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Clonidine and Secretin

supplement:

Secretin

Research Papers that Mention the Interaction

We demonstrated in 1962 that clonidine was able to annul the excito-secretory effects of secretin (a gastrointestinal hormone) on the pancreatic juice secretion of dogs whose pancreatic ducts had been previously cannulated [3].
Digestive Diseases and Sciences  •  2008  |  View Paper
Clonidine decreased the basal pancreatic secretion in anaesthetized rats and this action was completely reversed by yohimbine.
Subcutaneous and intracerebroventricular injections of clonidine in conscious rats induced a dose-dependent inhibition of basal pancreatic secretion involving volume, bicarbonate output and protein output with an ED50 of about 10 micrograms/kg.
European journal of pharmacology  •  1981  |  View Paper