Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Clonidine and Quinine

supplement:

Quinine

Research Papers that Mention the Interaction

Quinine reduced specific binding incompletely (73%) with Ki values of 75 nM and 133 mM. Clonidine , N‐allyl‐clonidine (alinidine), and quinine inhibited native KATP channels as well as Kir6.2DC26 channels.
Annals of the New York Academy of Sciences  •  2003  |  View Paper
Many drugs such as clonidine, guanabenz, methamphetamine, imipramine, clomipramine, nortriptyline, quinine , xylazine, ephedrine, and diphenhydramine strongly inhibited the [3H]clonidine uptake with Ki values between 0.15 and 1 mM.ConclusionsClonidine is transported by a carrier-mediated process.
Pharmaceutical Research  •  2005  |  View Paper
Diphenhydramine, guanabenz, procainamide, tryptamine, quinine , and quinidine, but not choline markedly inhibited clonidine uptake.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  2004  |  View Paper
Several cationic drugs such as clonidine, quinine , quinidine, and diphenhydramine strongly inhibited the [3H]clonidine uptake with Ki values around 1 mM. Conclusions.
Pharmaceutical Research  •  2004  |  View Paper