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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Clonidine accumulation in lung alveolar A549 cells was found to be temperature- and pH-dependent; it was saturable, … affinity constant (Km) value of 569.4 μM. Various pneumophilic drugs, including amitriptyline, verapamil, propranolol, chlorpromazine, imipramine, and quinidine, … clonidine uptake in A549 cells, in a … at least some of them.”
Carrier-mediated uptake of clonidine in cultured human lung cells“Diphenhydramine, guanabenz, procainamide, tryptamine, quinine, and quinidine , but not choline markedly inhibited clonidine uptake.”
“Several cationic drugs such as clonidine, quinine, quinidine , and diphenhydramine strongly inhibited the [3H]clonidine uptake with Ki values around 1 mM. Conclusions.”
“On the other hand, lipophilic cationic drugs, such as clonidine , bisoprolol, diphenhydramine, pyrilamine, and imipramine, significantly decreased the uptake of quinidine in MDCK cells.”
Presence of an H+/Quinidine Antiport System in Madin–Darby Canine Kidney Cells“ Quinidine is effective in decreasing specific [3H]clonidine binding to the alpha 2 receptor within the range of therapeutic blood levels (Ki = 6 x 10 (-8) M).”
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