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Last Updated: 3 years ago

Possible Interaction: Clonidine and Quinidine



Research Papers that Mention the Interaction

Clonidine accumulation in lung alveolar A549 cells was found to be temperature- and pH-dependent; it was saturable, … affinity constant (Km) value of 569.4 μM. Various pneumophilic drugs, including amitriptyline, verapamil, propranolol, chlorpromazine, imipramine, and quinidine, … clonidine uptake in A549 cells, in a … at least some of them.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2018  |  View Paper
Diphenhydramine, guanabenz, procainamide, tryptamine, quinine, and quinidine , but not choline markedly inhibited clonidine uptake.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  2004  |  View Paper
Several cationic drugs such as clonidine, quinine, quinidine , and diphenhydramine strongly inhibited the [3H]clonidine uptake with Ki values around 1 mM. Conclusions.
Pharmaceutical Research  •  2004  |  View Paper
On the other hand, lipophilic cationic drugs, such as clonidine , bisoprolol, diphenhydramine, pyrilamine, and imipramine, significantly decreased the uptake of quinidine in MDCK cells.
European Journal of Drug Metabolism and Pharmacokinetics  •  2015  |  View Paper
Quinidine is effective in decreasing specific [3H]clonidine binding to the alpha 2 receptor within the range of therapeutic blood levels (Ki = 6 x 10 (-8) M).
European journal of pharmacology  •  1980  |  View Paper